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NUCLEAR REPROGRAMMING
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DeCS
Descriptor
English
:
Nuclear Reprogramming
Descriptor
Spanish
:
Reprogramación Nuclear
Descriptor
Portuguese
:
Reprogramação Nuclear
Tree Number:
G05.355.680
Definition
English
:
The process that reverts CELL NUCLEI of fully differentiated somatic
cells
to a pluripotent or totipotent
state
. This process can be achieved to a certain extent by
NUCLEAR TRANSFER TECHNIQUES
, such as fusing somatic cell nuclei with enucleated pluripotent
embryonic stem cells
or enucleated totipotent
oocytes
.
GENE EXPRESSION PROFILING
of the fused
hybrid cells
is used to determine the degree of reprogramming. Dramatic results of
nuclear reprogramming
include the generation of cloned
mammals
, such as Dolly the
sheep
in 1997.
See Related
English
:
Nuclear Transfer Techniques
History Note
English
:
2007
Allowable Qualifiers
English
:
DE
drug effects
ES
ethics
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
52479
Unique Identifier:
D053708
Occurrence in VHL
:
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